6533b7d5fe1ef96bd1263eec

RESEARCH PRODUCT

Sensitization to the rewarding effects of morphine depends on dopamine

Marta Rodríguez-ariasCarmen ManzanedoJosé MiñarroMaría A. Aguilar

subject

Malemedicine.medical_specialtyDopamine(+)-NaloxonePharmacologyReceptors DopamineMicechemistry.chemical_compoundRewardInternal medicineDopamine receptor D2Conditioning PsychologicalHaloperidolmedicineAnimalsSensitizationRacloprideSCH-23390MorphineNaloxoneGeneral NeuroscienceBenzazepinesConditioned place preferenceEndocrinologymedicine.anatomical_structurechemistryMorphinemedicine.drug

description

The influence of dopamine (DA) on sensitization to the rewarding effects of morphine was evaluated. The effects of pre-treatment with saline or morphine plus naloxone, CGS 10746B, haloperidol, SCH 23390 and raclopride, on the place conditioning induced by 2 mg/kg morphine were evaluated. This dose was ineffective in saline pre-treated animals but induced a clear conditioned place preference in mice pre-treated with morphine, CGS 10746B or haloperidol. Conversely, animals pre-treated with morphine plus naloxone, CGS 10746B, SCH 23390, raclopride and the high dose of haloperidol did not acquire place preference. Our results demonstrated that DA release and subsequent DA D1 and D2 receptor activation is essential for the development of sensitization to the rewarding effects of morphine.

yearjournalcountryeditionlanguage
2005-01-27NeuroReport
https://doi.org/10.1097/00001756-200502080-00028