Folding induced supramolecular assembly into pH-responsive nanorods with a protein repellent shell

6533b7d5fe1ef96bd1263f10

RESEARCH PRODUCT

Folding induced supramolecular assembly into pH-responsive nanorods with a protein repellent shell

Pol Besenius Matthias Barz Daniel Spitzer Kristina Klinker Meike Schinnerer Ronja Otter

subject

Human blood Chemistry Metals and Alloys A protein 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Antiparallel (biochemistry)01 natural sciences Pentapeptide repeat Blood proteins Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Supramolecular assembly Materials Chemistry Ceramics and Composites Biophysics Nanorod 0210 nano-technology Conjugate

description

We report the synthesis of ABA' triblock peptide-polysarcosine-peptide conjugates featuring two complementary phenylalanine-histidine pentapeptide strands A/A'. These sequences encode for antiparallel beta-sheet formation into folded conjugates, which promote the self-assembly into polysarcosine-shielded core-shell nanorods. These do not cause aggregation of serum proteins in human blood plasma underlining an enhanced stability.

year	journal	country	edition	language
2018-01-14

10.1039/c7cc08127h https://hdl.handle.net/1887/3201490

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