6533b7d5fe1ef96bd1263f1e
RESEARCH PRODUCT
Easy access to heterobimetallic complexes for medical imaging applications via microwave-enhanced cycloaddition
Claude P. GrosSandrine PacqueletNicolas DesboisClément MichelinAdrien Duboissubject
NOTAmicrowavePhotochemistryFull Research Paperlcsh:QD241-441Metalchemistry.chemical_compoundlcsh:Organic chemistrycorroleDOTACorrolelcsh:ScienceOrganic ChemistryPorphyrinCombinatorial chemistryCycloadditionChemistryDOTAchemistryYield (chemistry)visual_artclick chemistryClick chemistryvisual_art.visual_art_mediumlcsh:QporphyrinMicrowavedescription
The Cu(I)-catalysed Huisgen cycloaddition, known as “click” reaction, has been applied to the synthesis of a range of triazole-linked porphyrin/corrole to DOTA/NOTA derivatives. Microwave irradiation significantly accelerates the reaction. The synthesis of heterobimetallic complexes was easily achieved in up to 60% isolated yield. Heterobimetallic complexes were easily prepared as potential MRI/PET (SPECT) bimodal contrast agents incorporating one metal (Mn, Gd) for the enhancement of contrast for MRI applications and one “cold” metal (Cu, Ga, In) for future radionuclear imaging applications. Preliminary relaxivity measurements showed that the reported complexes are promising contrast agents (CA) in MRI.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-07-24 | Beilstein Journal of Organic Chemistry |