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RESEARCH PRODUCT
ChemInform Abstract: Synthesis and Chemical Reactivity of 5-Methoxy-2-vinyl-4-azaindoles.
José Sepúlveda-arquesMohamed Djebouri SidiElena Zaballos-garcíaR. A. JonesL. Rodriguez-salvadorE. Gonzalez-rosendesubject
Dimethyl acetylenedicarboxylatechemistry.chemical_compoundAddition reactionchemistryYield (chemistry)technology industry and agricultureGeneral MedicineMedicinal chemistryDerivative (chemistry)Adductdescription
Abstract 2-Vinyl-4-azaindoles are less reactive with dienophiles than 2-vinylindoles. 5-Methoxy-2-vinyl-4-azaindole 2a and its 1-methyl derivative 2a reacts with N-phenylmaleimide to yield cycloadducts only under vigorous conditions. 2b produces a cycloadduct with dimethyl acetylenedicarboxylate, while 2a yields a Michael-type adduct. Reactions with more reactive dienophiles gave only polymeric products.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-08-03 | ChemInform |