6533b7d5fe1ef96bd126473f
RESEARCH PRODUCT
Molecular Search of New Active Drugs AgainstToxoplasma Gondii
Ramón García-domenechR. GozalbesJorge GalvezFrancis Derouinsubject
SulfamethoxazoleAndrographolideAntiprotozoal AgentsToxoplasma gondiiBioengineeringGeneral MedicinePharmacologyBiologybiology.organism_classificationVirologyTrimethoprimSulfonechemistry.chemical_compoundPyrimethaminechemistryparasitic diseasesDrug DiscoveryIc50 valuesmedicineAnimalsMolecular MedicineToxoplasmamedicine.drugdescription
Molecular connectivity has been applied to the search of new compounds with activity against the protozoan Toxoplasma gondii, using a stepwise linear discriminant analysis (SLDA) which is able to classify a compound according its activity either as active or as inactive. Among the selected compounds, andrographolide and dibenzotiophene sulfone stand out, both with IC50 values lower than 1 microgram/ml, which are comparable to these of drugs such as sulfamethoxazole, pyrimethamine and trimethoprim, with IC50 values equal to 1.1, 0.04 and 2.31 micrograms/ml, respectively. These results confirm the usefulness of our topological approach for the selection and design of new-lead drugs active against Toxoplasma gondii.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-02-01 | SAR and QSAR in Environmental Research |