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RESEARCH PRODUCT
Dependence of plasma pH on oxygen saturation
G. ThewsD. SchultehinrichsH.-j. Von Mengdensubject
Acid-Base EquilibriumPulmonary and Respiratory MedicineAdolescentPhysiologyChemistryPartial PressureAnalytical chemistryOxygenationVenous bloodPlasmaBuffersCarbon DioxideHydrogen-Ion ConcentrationOxygenBicarbonatesHemoglobinsBloodBiochemistryBlood plasmaLinear relationHumansBase excessOxygen saturationBlood phdescription
Abstract The influence of haemoglobin oxygenation on the pH value of the blood plasma of healthy adolescents was investigated at 38°C by varying the parameters CO2 pressure, Hb concentration and buffer bases. A total of 5000 measurements gave the following results: 1. 1. The pHs difference between oxygenated and deoxygenated blood increases with diminishing CO2 pressure and with increasing Hb concentration. There is a linear relation between the pHs changes and the O2 saturation of the haemoglobin. 2. 2. Quantitatively these relationships can be expressed by the following equation: δpHs = (8 − pH ox − log 0.03 Pco 2 ) · [Hb] 225 · (100 − So 2 100 where ΔpHs is the pHs difference between partially and fully oxygenated blood, pHOx represents the pH value of fully oxygenated blood, P co 2 the CO2 pressure in mm Hg, [Hb] the haemoglobin concentration in g% and S o 2 the O2 saturation in%. The difference of the base excess ABE between partially and fully oxygenated blood can be obtained from the following equation: δBE = (0.1 + 0.005 · [Hb]) · [Hb] · (100 − So 2 ) 100
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1969-02-01 | Respiration Physiology |