6533b7d5fe1ef96bd12647ff

RESEARCH PRODUCT

An oxidatively damaged G-quadruplex/hemin DNAzyme.

Mingpan ChengJiawei WangJielin ChenJun ZhouDavid MonchaudHuangxian JuJean-louis Mergny

subject

GuanineGuanineDeoxyribozyme010402 general chemistryG-quadruplex01 natural sciencesCatalysisOxidative damage03 medical and health scienceschemistry.chemical_compoundMaterials Chemistrypolycyclic compoundsheterocyclic compoundsBinding site[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM]030304 developmental biology0303 health sciencesMolecular StructureMetals and AlloysGeneral ChemistryDNA Catalyticequipment and supplies0104 chemical sciencesSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsG-QuadruplexeschemistryCeramics and CompositesBiophysicsOxidation-ReductionHemin

description

International audience; Oxidative damage of guanine to 8-oxoguanine triggers a partial and variable loss of G-quadruplex/hemin DNAzyme activity and provides clues to the mechanistic origins of DNAzyme deactivation, which originates from an interplay between decreased G-quadruplex stability, lower hemin affinity and a modification of the nature of hemin binding sites.

yearjournalcountryeditionlanguage
2020-01-18Chemical communications (Cambridge, England)
10.1039/c9cc09237dhttps://pubmed.ncbi.nlm.nih.gov/31950946