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RESEARCH PRODUCT
Hyperuricemia and high blood pressure at rest and during exercise: Guilty or innocent? The jury is still out
Luigi LattucaEmilio NardiGiuseppe MulèSantina Cottonesubject
Malemedicine.medical_specialtySettore MED/09 - Medicina InternaEndocrinology Diabetes and Metabolismmedia_common.quotation_subjectBlood PressureHyperuricemia030204 cardiovascular system & hematology03 medical and health scienceschemistry.chemical_compound0302 clinical medicineJuryInternal medicineInternal MedicinemedicineHumans030212 general & internal medicineHyperuricemiaRest (music)media_commonSettore MED/14 - Nefrologiabusiness.industryUric Acid and Hypertensionmedicine.diseaseUric AcidBlood pressurechemistryHypertensionGuiltCardiologyUric acidCardiology and Cardiovascular Medicinebusinessdescription
The authors investigated the hypothesis that high serum uric acid concentrations may be related to an exaggerated systolic blood pressure (SBP) response to maximal exercise testing in men with normotension, independent of potential confounding variables. In 4640 healthy men with normotension who underwent maximal treadmill exercise testing and fasting blood chemistry studies, including serum uric acid concentrations, an exaggerated SBP response, defined as SBP ≥ 210 mm Hg, was detected in 152 men (3.3%). After adjusting for potential confounders, participants in the highest quartile of serum uric acid (>6.6 mg/dL) had a higher odds ratio of demonstrating an exaggerated SBP to maximal exercise (odds ratio, 2.19; 95% confidence interval, 1.24–3.86) compared with participants in the lowest quartile of serum uric acid (<5.1 mg/dL). High serum uric acid concentrations are associated with an exaggerated SBP response to maximal exercise testing in men with normotension, independent of established coronary risk factors.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-02-19 | The Journal of Clinical Hypertension |