6533b7d5fe1ef96bd1264f2b
RESEARCH PRODUCT
Efficient Synthesis of Multifunctional Chelating Agents Based on Tetraazacycloalkanes
Claire BernhardFrédéric BoschettiNicolas SokIsabelle BaglinYoann RousselinPauline DésogèreFranck DenatChristine Gozesubject
Primary (chemistry)010405 organic chemistryLigandChemistryOrganic ChemistryCarbon skeletonRegioselectivity010402 general chemistry01 natural sciencesCombinatorial chemistry0104 chemical sciencesAmine gas treatingChelationPhysical and Theoretical Chemistrydescription
An efficient route has been developed for the synthesis of multifunctional tetraazacycloalkanes (in particular 1,4,7,10-tetraazacyclotridecane) incorporating an aminomethyl pendant arm on the carbon skeleton. Starting from the appropriate C-functionalized bisaminal-protected intermediate, the target macrocycles were easily obtained by means of a step-by-step introduction of the desired functional groups onto the free primary amine group, followed by deprotection of the bisaminal intermediates. This straightforward and versatile synthetic approach paves the way for the design of a new family of multifunctional chelators.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-08-23 | European Journal of Organic Chemistry |