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RESEARCH PRODUCT
ChemInform Abstract: Synthesis of New Asymmetric Xanthene Dyes via Catalyst-Free SNAr with Sulfur Nucleophiles.
Okan Osman OglouMark HelmMichaela Kotaskovasubject
Xanthenechemistry.chemical_compoundchemistryNucleophileNucleophilic aromatic substitutionLabellingMoietychemistry.chemical_elementGeneral MedicineCombinatorial chemistrySulfurCatalysisMacromoleculedescription
Addition of a single functional handle to the tricyclic moiety of fluorescein results in asymmetric xanthene dyes. Our synthesis of a new class of asymmetric xanthenes proceeds via an unusual SNAr with sulfur nucleophiles on electron rich aromatic xanthenes scaffolds in the absence of a metal catalyst. The resulting 3′-thioethers exhibit high photostability and are conveniently converted into reactive dyes for macromolecule labelling.
year | journal | country | edition | language |
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2014-10-16 | ChemInform |