Tissue microenvironment dictates the fate and tumor-suppressive function of type 3 ILCs

6533b7d5fe1ef96bd12650e2

RESEARCH PRODUCT

Tissue microenvironment dictates the fate and tumor-suppressive function of type 3 ILCs

Sara H. Burkhard Isabel Ohs Christoph S.n. Klose Sebastian J. Arnold Kathrin Nussbaum Andreas Diefenbach Florian Mair Burkhard Becher Sonia Tugues

subject

0301 basic medicine medicine.medical_treatment Immunology 314 610 Medicine & health Biology 10263 Institute of Experimental Immunology Article 311 03 medical and health sciences Mice RAR-related orphan receptor gamma Cell Line Tumor medicine Immunology and Allergy Animals Lymphocytes skin and connective tissue diseases Transcription factor Research Articles Mice Knockout 2403 Immunology Innate lymphoid cell Neoplasms Experimental Nuclear Receptor Subfamily 1 Group F Member 3 Phenotype Cell biology body regions Killer Cells Natural Mice Inbred C57BL 030104 developmental biology Cytokine Cellular Microenvironment Cell culture Tumor progression Interleukin 12 2723 Immunology and Allergy Cytokines 570 Life sciences; biology Transcription Factors

description

Nussbaum et al. found that tumor suppression through innate lymphoid cells (ILCs) cannot be predicted solely based on the ILC phenotype and lineage but that their immune properties are shaped both by their ontogeny and by the tissue microenvironment they reside in.

year	journal	country	edition	language
2017-01-01

10.5167/uzh-140357 https://www.zora.uzh.ch/id/eprint/140357/

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