Expression of Peripheral Node Addressins by Plasmacytic Plaque of Children, APACHE, TRAPP, and Primary Cutaneous Angioplasmacellular Hyperplasia.

6533b7d5fe1ef96bd12650ef

RESEARCH PRODUCT

Expression of Peripheral Node Addressins by Plasmacytic Plaque of Children, APACHE, TRAPP, and Primary Cutaneous Angioplasmacellular Hyperplasia.

Maria T. Fernández-figueras Angel Fernandez-flores Carlos Monteagudo José M. Suárez Peñaranda Gonzalo De Toro Werner Kempf César Cosme ÁLvarez Cuesta

subject

Adult Male Pathology medicine.medical_specialty Histology Adolescent Plasma Cells Immunoglobulins Pathology and Forensic Medicine Diagnosis Differential 030207 dermatology & venereal diseases 03 medical and health sciences Young Adult 0302 clinical medicine Immunophenotyping Mucoproteins Pseudolymphoma Addressin medicine Pseudolymphoma Humans Skin pathology Child Aged Skin Aged 80 and over Hyperplasia biology business.industry Hyperplasia Middle Aged medicine.disease Immunohistochemistry Peripheral Angiokeratoma Medical Laboratory Technology 030220 oncology & carcinogenesis Child Preschool biology.protein Immunohistochemistry Female Lymph Nodes business Cell Adhesion Molecules Angiokeratoma

description

High-endothelial venules are a common feature of 3 types of cutaneous pseudolymphomas: pretibial lymphoplasmacytic plaque (PLP) of children, acral pseudolymphomatous angiokeratoma of children (APACHE), and T-cell rich angiomatoid polypoid pseudolymphoma (TRAPP). In addition, primary cutaneous angioplasmacellular hyperplasia (PCAH) overlaps with these other 3 conditions. We intend to study the expression of peripheral node addressins in PLP, APACHE, TRAPP, and PCAH. We studied 1 case of PLP, 2 cases of APACHE, 2 cases of TRAPP, and 2 cases of PCAH. Immunostainings for MECA-79 and WT-1 were obtained in all cases. All cases showed a dense lymphohistiocytic dermal inflammatory infiltrate with abundant plasma cells. In addition, HEV were prominent in all cases. Cases of PLP, APACHE, and TRAPP expressed MECA-1. Cases of PCAH did not express MECA-1. Although PLP, APACHE, and TRAPP seem to fall under the same morphologic spectrum with different clinical representations, PCAH seems to be a different entity, with histopathologic peculiarities and a different immunophenotype.

year	journal	country	edition	language
2018-07-01	Applied immunohistochemistrymolecular morphology : AIMM

10.1097/pai.0000000000000433 https://pubmed.ncbi.nlm.nih.gov/29994799