6533b7d5fe1ef96bd1265160
RESEARCH PRODUCT
Tetramethylguanidine (TMG)-catalyzed addition of dialkyl phosphites to α,β-unsaturated carbonyl compounds, alkenenitriles, aldehydes, ketones and imines
Francesco Paolo InvidiataGian Piero PolliniRiccardo RondaninMonica ManferdiniMarinella RobertiIlaria LamprontiDaniele Simonisubject
chemistry.chemical_compoundChemistryOrganic ChemistryDrug DiscoverySynthonOrganic chemistryBiochemistryPhosphonateCatalysisdescription
Abstract Tetramethylguanidine-catalyzed addition of dialkyl phosphites to α,β-unsaturated carbonyl compounds, alkenenitriles, aldehydes and ketones constitutes a practical route to a variety of phosphonate synthons. The very mild conditions employed, together with the short reaction times, make the procedure highly versatile and tolerant to a range of functionalities. The proposed methodology is also convenient for the preparation of α-aminophosphonates.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-10-01 |