6533b7d5fe1ef96bd126523a

RESEARCH PRODUCT

Polyurethane and PTFE membranes for guided bone regeneration: histopathological and ultrastructural evaluation.

Ivan BalducciLuís Guilherme Scavone De MacedoNelson Luiz De MacedoAdriana Socorro Ferreira Monteiro

subject

MaleBone RegenerationBiocompatibilitybone substitutesPolyurethanesBone and Boneschemistry.chemical_compoundbone regenerationmedicineAnimalsRats WistarBone regenerationGeneral DentistryPolytetrafluoroethylenePolyurethanepolytetrafluoroethylenePolytetrafluoroethyleneGuided tissue regenerationGuided Tissue RegenerationGranulation tissueMembranes ArtificialAnatomy:CIENCIAS MÉDICAS [UNESCO]RatsMembranemedicine.anatomical_structureOtorhinolaryngologychemistryGiant cellpolyurethaneUNESCO::CIENCIAS MÉDICASUltrastructureSurgeryartificial membranesBiomedical engineering

description

Made available in DSpace on 2013-08-12T18:17:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-03-01 Made available in DSpace on 2013-09-30T18:35:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-03-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T14:04:24Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T14:04:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-03-01 Objective: The purpose of this study was to research a membrane material for use in guided bone regeneration. Study design: In this study, 25 male Wistar rats were used to analyze the biocompatibility and degradation process of biomembranes. The morphological changes in subcutaneous implantations were assessed after 7, 14, 21, 28 and 70 days. The materials were made of polyurethane polymer (AUG) obtained from vegetal oil (Ricinus communis) and polytetrafluoroethylene membrane (PTFE). The surface characteristics of the physical barriers in scanning electronic microscopic (SEM) were also evaluated. Results: In both groups, the initial histological analysis showed moderate inflammatory infiltrate, which was predominantly polymorphonuclear. There was also a presence of edema, which was gradually replaced by granulation tissue, culminating in a fibrous capsule. In the AUG group, some multinucleated giant cells were present in the contact interface, with the space previously occupied by the material. However, membrane degradation was not observed during the period studied. According to the present SEM findings, porosity was not detected in the AUG or PTFE membranes. Conclusion: The researched material is biocompatible and the degradation process is extremely slow or may not even occur at all. São Paulo State Univ, Dept Diag & Surg, Sao Jose dos Campos Dent Sch, UNESP,Periodont Div, BR-12245000 Sao Jose Dos Campos, SP, Brazil São Paulo State Univ, Dept Biosci & Oral Diagnost, Sao Jose dos Campos Dent Sch, UNESP, BR-12245000 Sao Jose Dos Campos, SP, Brazil São Paulo State Univ, Dept Dent Mat & Prosthesis, Sao Jose dos Campos Dent Sch, UNESP, BR-12245000 Sao Jose Dos Campos, SP, Brazil São Paulo State Univ, Dept Social Dent, Sao Jose dos Campos Dent Sch, UNESP,Biostat Div, BR-12245000 Sao Jose Dos Campos, SP, Brazil São Paulo State Univ, Pediat Clin, Sao Jose dos Campos Dent Sch, UNESP,Biostat Div, BR-12245000 Sao Jose Dos Campos, SP, Brazil São Paulo State Univ, Dept Diag & Surg, Sao Jose dos Campos Dent Sch, UNESP,Periodont Div, BR-12245000 Sao Jose Dos Campos, SP, Brazil São Paulo State Univ, Dept Biosci & Oral Diagnost, Sao Jose dos Campos Dent Sch, UNESP, BR-12245000 Sao Jose Dos Campos, SP, Brazil São Paulo State Univ, Dept Dent Mat & Prosthesis, Sao Jose dos Campos Dent Sch, UNESP, BR-12245000 Sao Jose Dos Campos, SP, Brazil São Paulo State Univ, Dept Social Dent, Sao Jose dos Campos Dent Sch, UNESP,Biostat Div, BR-12245000 Sao Jose Dos Campos, SP, Brazil São Paulo State Univ, Pediat Clin, Sao Jose dos Campos Dent Sch, UNESP,Biostat Div, BR-12245000 Sao Jose Dos Campos, SP, Brazil

yearjournalcountryeditionlanguage
2010-01-01Medicina oral, patologia oral y cirugia bucal
10.4317/medoral.15.e401https://pubmed.ncbi.nlm.nih.gov/19767699