6533b7d5fe1ef96bd1265387
RESEARCH PRODUCT
Nucleation and accretion of bioelastomeric fibers at biological temperatures and low concentrations.
M. Ugo PlamaM. Ugo PlamaDan W. UrryDan W. UrryKari U. PrasadKari U. PrasadFrancesco SciortinoFrancesco Sciortinosubject
Hydrodynamic radiusChemical PhenomenaLightBiophysicsNucleationMineralogyBiochemistryInstabilityLight scatteringBiopolymersMetastabilityScattering RadiationMolecular BiologyPhase diagramchemistry.chemical_classificationAccretion (meteorology)ChemistryChemistry PhysicalTemperatureCell BiologyPolymerElasticityElastinKineticsChemical physicsPeptidesdescription
Quasi-elastic light scattering (QELS) studies are reported, which address the early stages of aggregation of the polypentamer poly(VPGVG). This reflects the major primary structural feature of native elastin. The study is focused on the region of the phase diagram which in both its temperature and concentration range is closest to the state of affairs occurring in the course of bioelastogenesis by progressive synthesis of the precursor protein. Results here reported allow for the first time a self-consistent view of the physics of elastogenesis, and specify the role of the region of metastability and of that of instability of the phase diagram in the non-chaotic, orderly formation of elastomeric fibers.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1988-12-01 | Biochemical and biophysical research communications |