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RESEARCH PRODUCT

Collateral Sensitivity in Drug-Resistant Tumor Cells

Mohamed E.m. SaeedHenry Johannes GretenThomas Efferth

subject

ChemotherapybiologyCollateralbusiness.industrymedicine.medical_treatmentTumor cellsDrug resistancePhenotypeMultiple drug resistancebiology.proteinmedicineCancer researchTreatment strategybusinessP-glycoprotein

description

Collateral sensitivity is a term for the hypersensitivity of otherwise drug-resistant cells. The selective killing of tumor cells by drugs exerting collateral sensitivity might be used as a novel treatment strategy. In this chapter, we give an overview on drug resistance phenotypes with known collateral sensitivities; furthermore, their molecular and cellular mechanisms were discussed to explain mediation of these hypersensitivities.

yearjournalcountryeditionlanguage
2013-01-01
https://doi.org/10.1007/978-1-4614-7070-0_10