6533b7d6fe1ef96bd1265a1d
RESEARCH PRODUCT
Alendronate-related oral mucosa ulcerations
Miguel ÁNgel González-molesJose V Bagán-sebastiánsubject
DrugCancer Researchmedicine.medical_specialtyBone diseasebusiness.industryAlendronic acidmedia_common.quotation_subjectOsteoporosismedicine.diseaseDermatologyPathology and Forensic MedicineSurgerymedicine.anatomical_structureOtorhinolaryngologymedicinePeriodonticsOral SurgeryOral mucosaAdverse effectbusinessComplicationAdverse drug reactionmedicine.drugmedia_commondescription
Alendronate is widely used in the treatment of osteoporosis and other bone diseases. Although it is considered a well-tolerated drug, there are numerous reports of adverse effects on the mucosa in the upper aerodigestive tract, with oesophagitis as the most common complication. The strict regulations for the proper administration of the drug indicate that these side effects might well be the result of a direct, irritant mechanism on the upper aerodigestive tract. We present two clinical cases of patients who developed extensive palatal ulcers as a result of taking alendronate. We discuss possible mechanisms implicated in the production of the ulcers and some clinical factors of interest.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-11-01 | Journal of Oral Pathology & Medicine |