6533b7d6fe1ef96bd1265b8e
RESEARCH PRODUCT
INULIN BASED HYDROGEL FOR ORAL DELIVERY OF FLUTAMIDE: PREPARATION, CHARACTERIZATION AND IN VIVO RELEASE STUDIES
Gaetano GiammonaGaetano GiammonaFilippo CalascibettaCalogero FioricaGiovanna PitarresiMario GiorgiDaniela Triolosubject
MalePolymers and PlasticsInulinAdministration OralBiological AvailabilityBioengineeringPharmacologyFlutamideBiomaterialschemistry.chemical_compoundDogsDrug Delivery SystemsIn vivoMaterials ChemistryDistribution (pharmacology)AnimalsHypoglycemic AgentsInsulinActive metabolitetechnology industry and agricultureAndrogen AntagonistsHydrogelsIn vitroFlutamideBioavailabilitychemistrySelf-healing hydrogelsBiotechnologyHalf-Lifedescription
The ability of a hydrogel obtained by crosslinking INUDV and PEGBa to facilitate sustained release of flutamide is examined. The hydrogel is prepared in pH = 7.4 PBS and no toxic solvents or catalysts are used. It is recovered in microparticulate form and its size distribution is determined. Mucoadhesive properties are evaluated in vitro by reproducing gastrointestinal conditions. Flutamide is loaded into the hydrogel using a post-fabrication encapsulation procedure that allows a drug loading comparable to that of market tablets. Drug-loaded microparticles are orally administered to cross-bred dogs and the in vivo study demonstrates their ability to prolong the half-life of the principal active metabolite approximately threefold and to significantly increase its bioavailability.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-01-05 |