6533b7d6fe1ef96bd1265b90

RESEARCH PRODUCT

Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles

Manuel Bañó-poloLuis Martínez-gilManuel M. Sánchez Del PinoAlberto MassoliIsmael MingarroRubén LéonMaria Jesus Garcia-murria

subject

Microbiology (medical)Virologiavirusestechnology industry and agriculturevirus diseasesMicrobiologiaInfectious and parasitic diseasesRC109-216macromolecular substancesvirus-like particlesMicrobiologyQR1-502virologybody regionssars-cov-2Infectious Diseasesmembrane disaggregationcetylpyridinium chlorideOriginal ArticleDentistry (miscellaneous)Research Article

description

ABSTRACT Background SARS-CoV-2 is continuously disseminating worldwide. The development of strategies to break transmission is mandatory. Aim of the study To investigate the potential of cetylpyridinium chloride (CPC) as a viral inhibitor. Methods SARS-CoV-2 Virus Like-Particles (VLPs) were incubated with CPC, a potent surfactant routinely included in mouthwash preparations. Results Concentrations of 0.05% CPC (w/v) commonly used in mouthwash preparations are sufficient to promote the rupture of SARS-CoV-2 VLP membranes. Conclusion Including CPC in mouthwashes could be a prophylactic strategy to keep SARS-CoV-2 from spreading.

yearjournalcountryeditionlanguage
2022-12-01Journal of Oral Microbiology
https://doi.org/10.1080/20002297.2022.2030094