Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population

6533b7d6fe1ef96bd1265ba4

RESEARCH PRODUCT

Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population

Raul Martinez-lacruz José I. González José V Sorlí Carolina Ortega-azorín Vicente Zanon-moreno Rocío Barragán Rebeca Fernández-carrión Dolores Corella Olga Portolés Emilio Ros Jose M. Ordovas Montserrat Fitó Eva M. Asensio Oscar Coltell Ignacio M. Gimenez-alba

subject

Male 0301 basic medicine Physiology Pilot Projects Genome-wide association study 030204 cardiovascular system & hematology Mediterranean Diet Mediterranean Linkage Disequilibrium chemistry.chemical_compound Nutrigenomics 0302 clinical medicine GWAS Glucuronosyltransferase Metabolic Syndrome education.field_of_study Nutrition and Dietetics Mediterranean Region Middle Aged Jaundice Female medicine.symptom bilirubin Genotype Bilirubin Population Single-nucleotide polymorphism Polymorphism Single Nucleotide Article 03 medical and health sciences Sex Factors Gene-diet interaction medicine gene-diet interaction Humans SNP Sex-specific education Life Style Aged Genetic association business.industry Bilirubin medicine.disease Diet sex-specific Cross-Sectional Studies 030104 developmental biology chemistry UGT1A1 Metabolic syndrome business Genome-Wide Association Study Food Science

description

Although, for decades, increased serum bilirubin concentrations were considered a threatening sign of underlying liver disease and had been associated with neonatal jaundice, data from recent years show that bilirubin is a powerful antioxidant and suggest that slightly increased serum bilirubin concentrations are protective against oxidative stress-related diseases, such as cardiovascular diseases. Therefore, a better understanding of the gene-diet interactions in determining serum bilirubin concentrations is needed. None of the previous genome-wide association studies (GWAS) on bilirubin concentrations has been stratified by sex. Therefore, considering the increasing interest in incorporating the gender perspective into nutritional genomics, our main aim was to carry out a GWAS on total serum bilirubin concentrations in a Mediterranean population with metabolic syndrome, stratified by sex. Our secondary aim was to explore, as a pilot study, the presence of gene-diet interactions at the GWAS level. We included 430 participants (188 men and 242 women, aged 55&ndash

year	journal	country	edition	language
2019-01-04

10.3390/nu11010090 http://hdl.handle.net/20.500.12105/7155