6533b7d6fe1ef96bd1265cee
RESEARCH PRODUCT
Interferon decreases serum lipid peroxidation products of hepatitis C patients
Angel RayaJoaquín RomáMiguel A. SerraJ M RodrigoFrancisco J. RomeroVictoria Higuerassubject
medicine.medical_specialtyThiobarbituric acidHIV InfectionsThiobarbituric Acid Reactive SubstancesBiochemistryGastroenterologyHepatitisLipid peroxidationchemistry.chemical_compoundInterferonPhysiology (medical)Internal medicineTBARSHumansMedicineIn patientHepatitis ChronicHepatitisSuperoxide Dismutasebusiness.industryHepatitis Cmedicine.diseaseHepatitis CLipidschemistryConcomitantAcute DiseaseImmunologyInterferonsLipid Peroxidationbusinessmedicine.drugdescription
Abstract Thiobarbituric acid reactive substances (TBARS) concentration in serum has been determined in healthy subjects and in patients suffering acute hepatitis and chronic cases of hepatitis C. Treatment with interferon of the chronic active hepatitis C patients, 5 × 10 6 U three times a week during 2 months, led in those patients whose SGPT activity normalized in serum, to a concomitant decrease in serum TBARS content. The possible theoretical involvement of peroxidation and antioxidants in this beneficial effect of interferon in hepatitis C patients is discussed. The results presented confirm the value of TBARS as laboratory test in the management of liver diseases and as a useful tool for the study of pathogenic and/or therapeutic mechanisms of this viral infection.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1994-01-01 | Free Radical Biology and Medicine |