6533b7d6fe1ef96bd1265d0b

RESEARCH PRODUCT

Semisynthesis and cytotoxicity of styryl-lactone derivatives.

Ghanem AtassiStephane LéonceNuria CabedoDiego CortesAlmudena BermejoDaniel Henri CaignardImmaculada Andreu

subject

StereochemistryNitro compoundMolecular ConformationPharmaceutical ScienceChemical synthesisAnalytical ChemistryLactonesMiceDrug DiscoveryTumor Cells CulturedAnimalsCytotoxicityLeukemia L1210Pharmacologychemistry.chemical_classificationNew GuineaPlants MedicinalBicyclic moleculeChemistryOrganic ChemistrySemisynthesisAntineoplastic Agents PhytogenicIn vitroComplementary and alternative medicineCell cultureMolecular MedicineDrug Screening Assays AntitumorLactone

description

The cytotoxicity and the cell-cycle action of altholactone (1), goniofufurone (2), and eight altholactone derivatives (5-12), were determined in vitro on L-1210 cells. Semisyntheses and structure-activity relationships of these compounds are described. The results of this study suggest that the cytotoxicity of altholactone (1), 11-nitro-altholactone (8), and 7-chloro-6,7-dihydroaltholactone (10) is due to the accumulation of the cells in the G2 + M phase of the cell cycle.

yearjournalcountryeditionlanguage
1999-09-10Journal of natural products
10.1021/np990089qhttps://pubmed.ncbi.nlm.nih.gov/10479313