6533b7d6fe1ef96bd1265d14
RESEARCH PRODUCT
Association of a CB1 Cannabinoid Receptor Gene (CNR1) polymorphism with severe alcohol dependence
Hans RommelspacherMargret R. HoeheUlrich FinckhLutz G. SchmidtJan HorodnickiJerzy SamochowiecJerzy SamochowiecJerzy SamochowiecEwa Fiszer-piosikBirgit Wendelsubject
Adultmedicine.medical_specialtyCannabinoid receptorGenotypeReceptors DrugToxicologyAlcohol Withdrawal SeizuresAlcohol Withdrawal DeliriumExonRisk FactorsPolymorphism (computer science)Internal medicinemental disordersGenotypemedicineHumansPharmacology (medical)AlleleReceptors CannabinoidPharmacologyPolymorphism Geneticbusiness.industryAlcohol Withdrawal DeliriumAlcoholismPsychiatry and Mental healthEndocrinologyDeliriumBrain stimulation rewardmedicine.symptombusinessdescription
Abstract Due to the involvement of the endogenous cannabinoid system in brain reward mechanisms a silent polymorphism (1359G/A; Thr453Thr) in the single coding exon of the CB1 human cannabinoid receptor gene ( CNR1 ) was analysed in 121 severely affected Caucasian alcoholics and 136 most likely non-alcoholic controls. The observed frequency of the A allele was 31.2% for controls and 42.1% for alcoholics with severe withdrawal syndromes ( P =0.010). Post-hoc exploration indicated that this allelic association resulted from an excess of the homozygous A/A genotype in patients with a history of alcohol delirium ( P =0.031, DF 2), suggesting s an increased risk of delirium (OR=2.45, 95% CI 1.14–5.25). This finding suggests that the homozygous genotype CNR1 1359A/A confers vulnerability to alcohol withdrawal delirium.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-02-14 | Drug and Alcohol Dependence |