6533b7d6fe1ef96bd1265d22

RESEARCH PRODUCT

A retrospective analysis of myelodysplastic syndromes with thrombocytosis: reclassification of the cases by WHO proposals.

Rosa ColladoIsabel NavarroJesús MartínezFelix CarbonellAna I. CabelloAmparo Miguel SosaRosa FerrerM. Angeles Ruiz

subject

MaleCancer ResearchPathologymedicine.medical_specialtyRefractory anemia with ringed sideroblastsWorld Health OrganizationAge Distributionhemic and lymphatic diseasesInternal medicinemedicineHumansSurvival analysisAgedRetrospective StudiesAged 80 and overThrombocytosisThrombocytosisbusiness.industryMyelodysplastic syndromesRetrospective cohort studyHematologyMiddle Agedmedicine.diseaseSurvival AnalysisOncologyInternational Prognostic Scoring SystemDysplasiaKaryotypingMyelodysplastic SyndromesFemalebusinessRefractory cytopenia with multilineage dysplasia

description

Myelodysplastic syndromes (MDS) show occasionally thrombocytosis, common feature of myeloproliferative diseases (MPD), with the overlapping of both disorders. Classically, thrombocytosis has been associated with some MDS subtypes: refractory anaemia with ringed sideroblasts (RARS), 5q- syndrome and those MDS with 3q chromosome rearrangements. The recent WHO classification recognises an unclassifiable MDS/MPD category including some of these disorders. Our aim is to determine the frequency of presentation, subtype classification and chromosome abnormalities of MDS with thrombocytosis diagnosed in our institution. Between 1990 and 2003 we studied 317 SMD patients according to FAB and WHO revised classifications and identified 22 cases presenting thrombocytosis associated with dysplasia, that are analysed in this article.

yearjournalcountryeditionlanguage
2004-05-17Leukemia research
10.1016/j.leukres.2004.07.014https://pubmed.ncbi.nlm.nih.gov/15725469