Inflammatory polyradiculoneuropathies: Clinical and immunological aspects, current therapies, and future perspectives

6533b7d6fe1ef96bd1265d2d

RESEARCH PRODUCT

Inflammatory polyradiculoneuropathies: Clinical and immunological aspects, current therapies, and future perspectives

Marco Onofrj Roberta Telese Vincenzo Di Stefano Michela Vitale Filomena Barbone Camilla Ferrante Antonio Di Muzio

subject

0301 basic medicine Pathology medicine.medical_specialty Nerve root Immunology lcsh:Medicine Chronic inflammatory demyelinating polyneuropathy medicine.disease_cause Guillain–Barré syndrome inflammatory neuropathies Autoimmunity 03 medical and health sciences chronic inflammatory demyelinating polyneuropathy 0302 clinical medicine peripheral nervous system medicine Immunology and Allergy Guillain-Barre syndrome business.industry autoimmunity lcsh:R medicine.disease Peripheral 030104 developmental biology medicine.anatomical_structure Peripheral nervous system Settore MED/26 - Neurologia neurophysiology business Infiltration (medical)030217 neurology & neurosurgery

description

Inflammatory polyradiculoneuropathies are heterogeneous disorders characterized by immune-mediated leukocyte infiltration of peripheral nerves and nerve roots leading to demyelination or axonal degeneration or both. Inflammatory polyradiculoneuropathies can be divided into acute and chronic: Guillain–Barré syndrome and chronic inflammatory demyelinating polyneuropathy and their variants. Despite major advances in immunology and molecular biology have been made in the last years, the pathogenesis of these disorders is not completely understood. This review summarizes the current literature of the clinical features and pathogenic mechanisms of inflammatory polyradiculoneuropathies and focuses on current therapies and new potential treatment for the future.

year	journal	country	edition	language
2020-11-27	European Journal of Inflammation

10.1177/2058739220942340 https://doaj.org/article/7bac241bd08a4257be51a97821b132e2

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