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RESEARCH PRODUCT
GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism
Catherine VergelyYves CottinLuc RochetteMarianne Zellersubject
Glial Cell Line-Derived Neurotrophic Factor ReceptorsGrowth Differentiation Factor 15Endocrinology Diabetes and MetabolismRegulatorApoptosisReviewBiologyVirus03 medical and health sciences0302 clinical medicineEndocrinologyMediatorironViral life cycleImmunity[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseasesPyroptosismedicineHumansImmunologic Factors030304 developmental biology0303 health sciences[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseasesSARS-CoV-2COVID-19Prognosismedicine.diseaseCOVID-19 Drug Treatment3. Good healthOxidative StresstherapeuticGDF15030220 oncology & carcinogenesisImmunology[SDV.IMM]Life Sciences [q-bio]/ImmunologyEndothelium VascularGDF15Cytokine Release SyndromeCytokine stormmetabolismTransforming growth factordescription
International audience; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic of respiratory and cardiovascular diseases, known as coronavirus disease 2019 (COVID-19). SARS-CoV-2 encodes the structural proteins spike (S), envelope (E), membrane (M), and nucleocapsid (N). The receptor-binding domain on the surface subunit S1 is responsible for attachment of the virus to angiotensin (Ang)-converting enzyme 2 (ACE2), which is highly expressed in host cells. The cytokine storm observed in patients with COVID-19 contributes to the endothelial vascular dysfunction, which can lead to acute respiratory distress syndrome, multiorgan failure, alteration in iron homeostasis, and death. Growth and differentiation factor 15 (GDF15), which belongs to the transforming growth factor-β (TGF-β) superfamily of proteins, has a pivotal role in the development and progression of diseases because of its role as a metabolic regulator. In COVID-19, GDF15 activity increases in response to tissue damage. GDF15 appears to be a strong predictor of poor outcomes in patients critically ill with COVID-19 and acts as an ‘inflammation-induced central mediator of tissue tolerance’ via its metabolic properties. In this review, we examine the potential properties of GDF15 as an emerging modulator of immunity in COVID-19 in association with iron metabolism. The virus life cycle in host cell provides potential targets for drug therapy.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-01-01 | Trends in Endocrinology and Metabolism |