6533b7d6fe1ef96bd126659c

RESEARCH PRODUCT

Technical Aspects for the Evaluation of Circulating Nucleic Acids (CNAs): Circulating Tumor DNA (ctDNA) and Circulating MicroRNAs

Marta CastigliaViviana BazanAntonio RussoMaría José SerranoMarcello CiaccioAlessandro Perez

subject

0301 basic medicineSalivabusiness.industryCancerDiseaseCirculating Nucleic Acids CNAs Circulating Tumor DNA ctDNA Circulating MicroRNAs microRNAsmedicine.diseaseMany body03 medical and health sciencesCirculating MicroRNA030104 developmental biology0302 clinical medicineCirculating tumor DNA030220 oncology & carcinogenesismicroRNACancer researchmedicineNucleic acidbusiness

description

Circulating nucleic acids (CNAs), for example, circulating tumor DNA (ctDNA) and circulating microRNA (miRNA), represent promising biomarkers in several diseases including cancer. They can be isolated from many body fluids, such as blood, saliva, and urine. Also ascites, cerebrospinal fluids, and pleural effusion may be considered as a source of CNAs, but with several and intrinsic limitations. Therefore, blood withdrawal represents one of the best sources for CNAs due to the very simple and minimally invasive way of sampling. Moreover, it can be repeated at different time points, giving the opportunity for a real-time monitoring of the disease.

yearjournalcountryeditionlanguage
2017-01-01
10.1007/978-3-319-55661-1_6http://hdl.handle.net/10447/245232