6533b7d6fe1ef96bd12666e4
RESEARCH PRODUCT
Changing associations between cognitive impairment and imaging in multiple sclerosis as the disease progresses.
David MillerJk SwantonMary SummersLisa CipolottiMaria A. RonSophia A. Pennysubject
AdultMalemedicine.medical_specialtyPathologyIntelligenceStatistics as TopicDiseaseAudiologyNeuropsychological Testsmultiple sclerosisLesionDisability EvaluationExecutive FunctionAtrophyMemorymedicineHumansOptic neuritisAttentionCognitive impairmentbusiness.industryMultiple sclerosisBrainCognitionMiddle AgedVerbal Learningmedicine.diseaseMagnetic Resonance ImagingPsychiatry and Mental healthCross-Sectional StudiesCohortDisease ProgressionFemaleNeurology (clinical)medicine.symptombusinessCognition DisordersFollow-Up Studiesdescription
The authors explored cross-sectional associations between MRI parameters (lesion metrics, brain volumes, magnetization transfer ratio histograms, and metabolite concentrations) and cognition in 61 patients who experienced clinically-isolated syndromes (CIS) 7 years earlier. IQ decline and poorer overall cognition were associated with T2 white-matter lesions, and slow information-processing with both T2 lesions and gray-matter atrophy. In a previous study of the same cohort, gray-matter atrophy measured shortly after CIS failed to predict development of cognitive impairment years later. Our findings suggest that gray-matter pathology, reflected by atrophy measurements, becomes increasingly important in determining cognition as MS progresses.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-05-21 |