6533b7d6fe1ef96bd1266828
RESEARCH PRODUCT
Altered elemental profile as indicator of homeostatic imbalance in pathogenesis of oral submucous fibrosis
Ranjan Rashmi PaulMiguel De La GuardiaM. Luisa CerveraArabinda K. DasJyotirmoy ChatterjeeKeya Chaudhurisubject
Pathologymedicine.medical_specialtyEndocrinology Diabetes and MetabolismClinical BiochemistryPhysiologyOral Submucous FibrosisBiologyOral cavityBiochemistryMass SpectrometryInorganic ChemistryPathogenesismedicineGenetic predispositionHomeostasisHumansOral mucosaBiochemistry (medical)Oral habitsGeneral Medicinemedicine.diseaseTrace ElementsPrecancerous conditionstomatognathic diseasesmedicine.anatomical_structureOral submucous fibrosisHomeostasisdescription
Oral submucous fibrosis (OSF) is a potential precancerous condition of the oral cavity and oropharynx. The etiopathogenesis of this complex precancerous condition is still obscure. In addition to deleterious oral habits, malnutrition, and possible genetic predisposition, altered bioelemental status is also likely to play an important role in its pathogenesis. The present study analyzed 68 elements by inductively coupled plasma-mass spectroscopy in oral mucosa of normal and OSF individuals and some interesting alterations in elemental profile in the diseased tissue have been noted, indicating a homeostatic imbalance. These bioelemental alterations leading to homeostatic imbalance might be considered as an important biological event in the pathogenesis of OSF.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-07-16 |