5’GCGC un 5’CGCG pārkares galus saturošu DNS oligonukleotīdu elektroforētiskās īpašības un vizualizācija atomspēka mikroskopā

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RESEARCH PRODUCT

5’GCGC un 5’CGCG pārkares galus saturošu DNS oligonukleotīdu elektroforētiskās īpašības un vizualizācija atomspēka mikroskopā

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Darbā tika apskatīta DNS ar 5’GCGC un 5’CGCG vienpavediena pārkares galu atkarīga migrācija poliakrilamīda gēla elektroforēzē un to saistīšanās efektivitātes noteikšana uz vizlas un grafēna virsmu ar atomspēku mikroskopu. Darbs pierādīja, ka pastāv oligonukleotīdu 5’GCGC un 5’CGCG vienpavediena pārkares galu un cilpu saturošo oligonukleotīdu atkarīga migrācijas anomālija. Oligonukleotīdu migrācija ir atkarīga no izmantotās temperatūras, gēla koncentrācijas un pievienotajiem joniem. Oligonukleotīdu saistīšanās efektivitāte ar vizlas virsmu ir atkarīga no: vienpavediena pārkares gala, cilpu saturošajiem oligonukleotīdiem un magnija jonu klātbūtnes. Atslēgas vārdi: DNS, elektroforēze, atomspēku mikroskops, pārkares gali

year	journal	country	edition	language
2014-01-01

https://dspace.lu.lv/dspace/handle/7/15888

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
  - PE2_2 Phenomenology of fundamental interactions
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SHSocial Sciences and Humanities
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