6533b7d6fe1ef96bd1266e27

RESEARCH PRODUCT

Other Types of Chaperonopathies

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description

A mechanism causing a chaperonopathy that is introduced in this chapter consists of the absence of a chaperone from the place where it is needed (i.e., chaperonopathies by misplacement). Also in this chapter are discussed the unfolded-protein response (UPR), chaperone-mediated autophagy (CMA), and illustrative examples of chaperonopathies by mistake, or collaborationism. In these conditions, one or more chaperones, apparently normal in structure, perform functions that favor disease rather than the contrary, hence the name of chaperonopathy by mistake or collaborationism (a molecule that ought to protect the cell and the organism promotes pathogenesis instead). Many examples of chaperonopathies by mistake have been identified involving various chaperones and co-chaperones, including a variety of cancers, and inflammatory and autoimmune conditions. The participation of Hsp60 in these disorders is analyzed in some detail. The potential role of this chaperone as autoantigen and/or as signal molecule is brought up to central stage in certain cancers, myasthenia gravis, Hashimoto’s thyroiditis, chronic obstructive pulmonary disease (COPD), and ulcerative colitis.