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RESEARCH PRODUCT

Experimental „Luxury Perfusion” in the Cerebral Cortex of the Cat

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Publisher Summary Preliminary studies have been performed, on the changes of cortical rCBF (Krypton- 85 Beta clearance technique) in response to a localized pressure applied to the cerebral cortex (suprasylvian gyrus) of 8 cats under Nembutal anesthesia (30 to 40 mg/kg bodyweight). No change in rCBF is found at regions as distant as the contralateral hemisphere. The increase of rCBF at the compressed site, during the compression, seems to be more marked in animals with higher blood (i.e. perfusion) pressure, and may be absent in cats with blood pressure of about 80 mm Hg. The augmentation of rCBF around the compressed area during the compression is always very marked, and after some time flow values over twice as high as the control values may be attained. During the entire length of our experiments (3 to 4 hours) we have not observed the hyperemia around the formerly compressed area to decrease back to the normal pre-compression values. The electrocorticogram shows a marked fastening of the activity and an increase of the manual frequency index around the compressed area (during and after compression), and a slowing of the activity as well as a pronoced decrease in the frequency index at the formerly compressed area when rCBF at this site has fallen to subnormal values. The above studies were performed by suggestion of Dr. N. A. Lassen (Copenhagen) in the laboratory of Dr. D. H. Ingvar (Lund). The electrocorticograms have been analysed by Dr. A. Hadjidimos.