6533b7d6fe1ef96bd1266fcb
RESEARCH PRODUCT
Response of isolated human ventricular myocardium to cyclic AMP and its dibutyryl derivative.
Thomas MeinertzH. ScholzK. WinterHermann Nawrathsubject
InotropeAdultmedicine.medical_specialtyHeart VentriclesDerivativePropranololIn Vitro TechniquesVentricular myocardiumInternal medicineDrug DiscoverymedicineCyclic AMPHumansPapillary muscleGenetics (clinical)Dose-Response Relationship Drugbusiness.industryHeartGeneral MedicineMiddle AgedPropranololC++ AMPElectric Stimulationmedicine.anatomical_structureEndocrinologyBucladesineMolecular MedicineTime to peakbusinessmedicine.drugdescription
The contractile responses to c-AMP and DB-c-AMP were studied in isolated electrically stimulated human papillary muscle strips. C-AMP (1×10−4 to 1×10−3 M) had no effect on contractile force in all of 6 human papillary muscle preparations studied. In contrast, DB-c-AMP (10−4 to 5×10−3 M) produced a concentration-dependent and reversible positive inotropic effect which was associated by a decrease in time to peak force and in relaxation time and which was not inhibited by 10−6 M propranolol. The possibility of a clinical applicability of DB-c-AMP is discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1974-07-01 | Klinische Wochenschrift |