6533b7d6fe1ef96bd1267073
RESEARCH PRODUCT
A Simple Cardiovascular Model for the Study of Hemorrhagic Shock
Dean NachmanFabio CibellaLinn Wagnert-avrahamLaura D'orsiAndrea De GaetanoAndrea De GaetanoLuciano Curciosubject
Article SubjectSwineComputer sciencemedia_common.quotation_subjectComputer applications to medicine. Medical informaticsR858-859.7Context (language use)Cardiovascular ModelShock HemorrhagicExperimental laboratorySettore ING-INF/01 - ElettronicaGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences0302 clinical medicineBattlefieldHemorrhagic ShockmedicineAnimalsHumansComputer Simulation030212 general & internal medicineSimplicitySettore MAT/07 - Fisica MatematicaSimple (philosophy)media_commonMathematical modelsGeneral Immunology and MicrobiologyApplied MathematicsHemodynamicsModels CardiovascularComputational Biology030208 emergency & critical care medicineMathematical ConceptsGeneral MedicinePrognosisAnimal modelsDisease Models AnimalMilitary PersonnelRisk analysis (engineering)Modeling and SimulationShock (circulatory)Settore ING-INF/06 - Bioingegneria Elettronica E InformaticaTime courseHemorrhagic shockCardiovascular Dynamicsmedicine.symptomResearch Articledescription
Hemorrhagic shock is the number one cause of death on the battlefield and in civilian trauma as well. Mathematical modeling has been applied in this context for decades; however, the formulation of a satisfactory model that is both practical and effective has yet to be achieved. This paper introduces an upgraded version of the 2007 Zenker model for hemorrhagic shock termed the ZenCur model that allows for a better description of the time course of relevant observations. Our study provides a simple but realistic mathematical description of cardiovascular dynamics that may be useful in the assessment and prognosis of hemorrhagic shock. This model is capable of replicating the changes in mean arterial pressure, heart rate, and cardiac output after the onset of bleeding (as observed in four experimental laboratory animals) and achieves a reasonable compromise between an overly detailed depiction of relevant mechanisms, on the one hand, and model simplicity, on the other. The former would require considerable simulations and entail burdensome interpretations. From a clinical standpoint, the goals of the new model are to predict survival and optimize the timing of therapy, in both civilian and military scenarios.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-01 |