6533b7d6fe1ef96bd126713e
RESEARCH PRODUCT
The visual orientation memory of Drosophila requires Foraging (PKG) upstream of Ignorant (RSK2) in ring neurons of the central complex
Burkhard PoeckMarla B. SokolowskiRoland StraussSara Kuntzsubject
MaleCognitive NeuroscienceGreen Fluorescent ProteinsForagingBrief CommunicationRibosomal Protein S6 Kinases 90-kDaStatistics NonparametricAnimals Genetically ModifiedCellular and Molecular NeuroscienceMemoryOrientationCyclic GMP-Dependent Protein KinasesAnimalsDrosophila ProteinsProtein kinase ADrosophilaNeuronsRegulation of gene expressionMemory DisordersCommunicationBehavior AnimalbiologyRecallWorking memorybusiness.industryfungiBrainbiology.organism_classificationNeuropsychology and Physiological PsychologyGene Expression RegulationDrosophilaFemaleSignal transductionbusinessNeurosciencePhotic StimulationDrosophila ProteinSignal Transductiondescription
Orientation and navigation in a complex environment requires path planning and recall to exert goal-driven behavior. Walking Drosophila flies possess a visual orientation memory for attractive targets which is localized in the central complex of the adult brain. Here we show that this type of working memory requires the cGMP-dependent protein kinase encoded by the foraging gene in just one type of ellipsoid-body ring neurons. Moreover, genetic and epistatic interaction studies provide evidence that Foraging functions upstream of the Ignorant Ribosomal-S6 Kinase 2, thus revealing a novel neuronal signaling pathway necessary for this type of memory in Drosophila.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-07-21 | Learning & Memory |