6533b7d6fe1ef96bd126714b
RESEARCH PRODUCT
Histamine and its possible role in cytolysis of white blood cells in guinea pigs sensitized with tubercle bacilli.
G. Gillissensubject
LysisLeukocytosisGuinea PigsTuberculinBacillusGram-Positive BacteriaTuberculinchemistry.chemical_compoundLeukocyte CountAntigenmedicineLeukocytesAnimalsNervous System Physiological PhenomenaLeukocytosisMultidisciplinarybiologyChemistryIn vitroCytolysisImmunologybiology.proteinmedicine.symptomAntibodyHistamineHistaminedescription
DELAYED or tuberculin-type sensitivity is–apart from some single publications–only transferable by white blood cells or peritoneal cells but not with humoral antibodies of sensitized organisms1. In vitro, after addition of antigen, a lysis of white blood cells2 is seen up to 35 per cent2. That effect is preceded by morphological changes3–5. Cytolysis in the presence of plasma will be discussed elsewhere. Labelled lymphoid cells of sensitized guinea pigs will be found after transfer to normal animals at the side of the dermal tuberculin reaction6. The importance of white cells is further revealed by the fact that the tuberculin reaction will be suppressed by a specific anti-lymphocytic serum7.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1962-11-01 | Nature |