6533b7d6fe1ef96bd1267177

RESEARCH PRODUCT

The Urticaria Activity Score-Validity, Reliability, and Responsiveness.

Adriane Peveling-oberhagPetra StaubachKarsten WellerNicole SchoepkeTatevik OhanyanMartin MetzTomasz HawroMarcus Maurer

subject

AdultMalemedicine.medical_specialtyUrticariaIntraclass correlationOmalizumabOmalizumabSeverity of Illness IndexDisease activity030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineQuality of lifeimmune system diseasesInternal medicineAnti-Allergic AgentsImmunology and AllergyMedicineHumansskin and connective tissue diseasesReceiver operating characteristicbusiness.industryReproducibility of ResultsDermatology Life Quality IndexMiddle AgedStandard error030228 respiratory systemChronic DiseasePhysical therapyPatient-reported outcomeFemalebusinessmedicine.drug

description

Background Chronic spontaneous urticaria is characterized by fluctuating symptoms. Its activity is assessed with the urticaria activity score (UAS). Two versions of the urticaria activity score used for 7 consecutive days (UAS7) are available: (1) The guideline-recommended UAS7, with once-daily documentation, and (2) the UAS7TD, with twice-daily documentation. Objective To better characterize both UAS7 versions with regard to their validity, reliability, sensitivity to change, minimal important difference (MID), and smallest detectable change (SDC). Methods One hundred thirty adult patients with chronic spontaneous urticaria completed both UAS7 versions, the Patients Global Assessment (PatGA) of disease activity, the Urticaria Control Test (UCT), the Chronic Urticaria Quality of Life Questionnaire, and the Dermatology Life Quality Index before and after the initiation of omalizumab therapy. Physicians completed a Physician Global Assessment of disease activity. Results The UAS7 and the UAS7TD showed high correlation with the activity anchor PatGA (r = 0.568, P Conclusions The UAS7 and UAS7TD show good and comparable clinimetric properties, including good sensitivity to change, and similar MIDs.

yearjournalcountryeditionlanguage
2018-07-01The journal of allergy and clinical immunology. In practice
10.1016/j.jaip.2017.10.001https://pubmed.ncbi.nlm.nih.gov/29128337