6533b7d6fe1ef96bd126717c
RESEARCH PRODUCT
Poly(alkylidenamines) dendrimers as scaffolds for the preparation of low-generation ruthenium based metallodendrimers
Helena TomásMarisol GouveiaJoão FigueiraKari RissanenJoão RodriguesManuel G. Jardimsubject
NitrileMetallodendrimersCationic polymerizationchemistry.chemical_elementPreparation of low-generation rutheniumPoly(alkylidenamines) dendrimersLow-generation rutheniumGeneral Chemistry.Combinatorial chemistryRutheniumCatalysisRutheniumFaculdade de Ciências Exatas e da Engenhariachemistry.chemical_compoundchemistryDendrimerMaterials ChemistryOrganic chemistryRuthenium Compoundsta116description
The aim of this article is to highlight the use of nitrile-functionalized poly(alkylidenamines) dendrimers as building blocks for the preparation of low-generation ruthenium based cationic metallodendrimers having in view potential biomedical applications. Air-stable poly(alkylidenamines) nitrile dendrimers, peripherally functionalized with the ruthenium moieties [Ru(η5-C5H5)(PPh3)2]+ or [RuCl(dppe)2]+, have been prepared, characterized and are being studied for their anticancer activity. The followed strategy is based on the biological advantages associated with low-generation dendrimers, the known activity of ruthenium compounds as anticancer drugs and the stability of these dendrimers at the physiological temperature.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-01-01 | New Journal of Chemistry |