Peptīda lunasīna un tā fragmentu efekti uz smadzeņu monoamīnu līmeni pelēm

6533b7d6fe1ef96bd1267457

RESEARCH PRODUCT

Peptīda lunasīna un tā fragmentu efekti uz smadzeņu monoamīnu līmeni pelēm

subject

monoamīni AEŠK/MS Farmācija lunasīna fragmenti lunasīns

description

Lunasīns ir jaunatklāts 43 aminoskābju garš peptīds, kas sākumā tika iegūts no sojas pupiņām. Pēc tam lunasīns tika atrasts arī graudaugos un citos augos. Lunasīnam piemīt pretvēža, pretiekaisuma darbība un spēja samazināt zema blīvuma lipoproteīnu līmeni asinīs. Tomēr lunasīna ietekme uz centrālo nervu sistēmu līdz šim ir ļoti maz pētīta. Darba mērķis bija pētīt lunasīna un tā fragmentu efektu uz monoamīnu saturu peļu smadzenēs, mērot monoamīnu līmeni ar augstas efektivitātes šķidruma hromatogrāfijas un masspektrometrijas tandēma metodi. Iegūtie rezultāti liecina, ka lunasīns un tripeptīds RGD pazemina serotonīna un noradrenalīna līmeni, bet C gala fragments 23-43 papildus tam samazina arī serotonīna un dopamīna metabolītu līmeni.

year	journal	country	edition	language
2015-01-01

https://dspace.lu.lv/dspace/handle/7/30926

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