6533b7d7fe1ef96bd1267868

RESEARCH PRODUCT

Pathophysiology of Cerebral Ischemia

Michael G. HennericiGünter KrämerWerner HackeHerman J. Gelmers

subject

medicine.medical_specialtyCardiac outputGlycogenChemistryIschemiachemistry.chemical_elementCarbohydrate metabolismmedicine.diseaseOxygenCerebral edemachemistry.chemical_compoundEndocrinologyCerebral blood flowInternal medicinemedicineCerebral perfusion pressure

description

The weight of the brain amounts to only 2% of total body weight, but it receives 15% of the cardiac output and uses 20% of the oxygen consumed by the body. The energy supply is provided almost exclusively by glucose metabolism. The substrate for this is stored in the brain in the form of glucose or glycogen and is sufficient to cover the energy requirements for only about 1 min. Consequently, there is a delicate equilibrium between oxygen and nutrient supply from the blood and the energy requirements of the brain. Disturbances in neurologic function appear after a few seconds of ischemia, although they are not necessarily persistent at first.

https://doi.org/10.1007/978-3-642-75548-4_2