6533b7d7fe1ef96bd12679b0
RESEARCH PRODUCT
Nickel‐Mediated Photoreductive Cross Coupling of Carboxylic Acid Derivatives for Ketone Synthesis**
Jan BrauerTill OpatzLisa Marie KammerElisabeth Quraishisubject
chemistry.chemical_classification540 Chemistry and allied sciencesRadicalCarboxylic acidOrganic ChemistryKetone synthesisCarboxylic AcidsPhotoredox catalysischemistry.chemical_elementGeneral ChemistryKetonesCombinatorial chemistryCatalysisMetalCoupling (electronics)NickelchemistryNickel540 ChemieReagentvisual_artvisual_art.visual_art_mediumPhotocatalysisOxidation-Reductiondescription
A simple photochemical, nickel-catalyzed synthesis of ketones starting from carboxylic acids is presented. Hantzsch-ester (HE) functions as a cheap, green and strong photoreductant upon visible-light excitation to facilitate radical generation and also engages in the Ni-catalytic cycle to restore the reactive species. With this dual role, HE allows for the coupling of a large variety of radicals (1°,2°, benzylic, α-oxy & α-amino) with aroyl and alkanoyl moieties, a new feature in the synthesis of ketones through dual nickel photoredox catalysis. With both precursors deriving from abundant carboxylic acids, this protocol is a welcome addition to the organic chemistry toolbox. The reaction proceeds under mild conditions without the need for toxic metal reagents or bases and shows a wide scope, including pharmaceuticals and complex molecular architectures.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-08-03 | Chemistry – A European Journal |