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RESEARCH PRODUCT
The respiratory virome in chronic obstructive pulmonary disease
Silvia CapillaXavier PomaresVicente Pérez-brocalAndrés MoyaEduard MonsóMateu EspasaMiguel GallegoMarian Garcia-nuñezConcepción MontónLaura MillaresRafaela Ferrarisubject
0301 basic medicinechronic obstructive diseasemetagenomicsviromebusiness.industryPulmonary diseaserespiratory tract diseases03 medical and health sciences030104 developmental biology0302 clinical medicine030228 respiratory systemVirologyImmunologyMedicineHuman viromeRespiratory systembusinessdescription
Aim: To characterize the respiratory virome in moderate/severe chronic obstructive pulmonary disease (COPD) patients using metagenomics, with healthy subjects as the reference. Patients & Methods: Sputum COPD samples were collected during stability and exacerbations with negative usual-care microbiologic analysis. Results: Eukaryotic viruses from the Anelloviridae, Herpesviridae and Retroviridae families and phages from the Shiphoviridae family were commonly found in COPD, and the respiratory virome in stability and noninfectious exacerbations showed a substantial similarity. DNA viruses with the highest relative abundance in COPD are Anelloviridae. Conclusion: These results support a colonizing role for eukaryotic viruses in COPD and highlight the importance of analyzing both DNA and RNA viruses when focusing on the respiratory virome.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-07-01 | Future Virology |