6533b7d7fe1ef96bd1267b8f
RESEARCH PRODUCT
Protective effect of mesoporous silica particles on encapsulated folates.
Pedro AmorósJosé M. BaratHanna DaubenschüzMaría Ruiz-ricoRamón Martínez-máñezÉDgar Pérez-esteveMaría D. Marcossubject
INGENIERIA DE LA CONSTRUCCIONFolic acidTECNOLOGIA DE ALIMENTOSLightSilicon dioxideBioactive moleculesPharmaceutical Science02 engineering and technology010402 general chemistry01 natural sciencesMesoporous silica particleschemistry.chemical_compoundFolic AcidMicroscopy Electron TransmissionControlled deliveryControlled releasechemistry.chemical_classificationChromatographyBiomoleculeQUIMICA INORGANICATemperatureGeneral Medicine5-FormyltetrahydrofolateMesoporous silicaHydrogen-Ion Concentration021001 nanoscience & nanotechnologySilicon DioxideControlled release0104 chemical sciencesBioavailabilitychemistryFolic acidChemical engineeringMicroscopy Electron ScanningEncapsulation0210 nano-technologyStabilityPorosityPowder DiffractionBiotechnologydescription
Mesoporous silica particles (MSPs) are considered suitable supports to design gated materials for the encapsulation of bioactive molecules. Folates are essential micronutrients which are sensitive to external agents that provoke nutritional deficiencies. Folates encapsulation in MSPs to prevent degradation and to allow their controlled delivery is a promising strategy. Nevertheless, no information exists about the protective effect of MSPs encapsulation to prevent their degradation. In this work, 5-formyltetrahydrofolate (FO) and folic acid (FA) were entrapped in MSPs functionalized with polyamines, which acted as pH-dependent molecular gates. The stability of free and entrapped vitamins after acidic pH, high temperature and light exposure was studied. The results showed the degradation of FO after high temperature and acidic pH, whereas entrapped FO displayed enhanced stability. Free FA was degraded by light, but MSPs stabilized the vitamin. The obtained results point toward the potential use of MSPs as candidates to enhance stability and to improve the bioavailability of functional biomolecules.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-08-01 | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V |