6533b7d7fe1ef96bd1267c7f
RESEARCH PRODUCT
Intranasal midazolam for treating acute respiratory crises in a woman with stiff person syndrome.
Marcello RomanoC TassorelliMargherita AlgeriGrazia CrescimannoEnrico AlfonsiGiuseppe CosentinoFilippo Brighinasubject
131040301 veterinary sciencesMidazolam116Stiff-Person Syndromerespiratory crisesSudden deathstiff person syndrome midazolam respiratory crises0403 veterinary science03 medical and health sciencesBenzodiazepines0302 clinical medicineMedicineHumansStiff syndromeRespiratory systemIntranasal midazolamintranasal midazolamClinical/Scientific NotesAdministration IntranasalRib cagebusiness.industry30304 agricultural and veterinary sciencesMiddle Agedmedicine.diseaseTrunkbody regionsDyspneaNeurologyAnesthesiaSettore MED/26 - NeurologiaFemaleNeurology (clinical)businessRespiratory Insufficiency030217 neurology & neurosurgeryStiff person syndromedescription
Stiff person syndrome (SPS) is a rare neurologic disorder characterized by progressively worsening rigidity and spasms of the axial and limb muscles. Dyspnea has been recently recognized as a common symptom in SPS,1 and life-threatening respiratory crises have been occasionally reported and suspected to be responsible for sudden death in these patients.2,3 The pathophysiologic mechanisms of these respiratory manifestations remain unclear. Some authors have hypothesized that rigidity and/or spasm of the muscles of the trunk could prevent normal rib cage movements and excursion of the diaphragm.1
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-01 | Neurology(R) neuroimmunologyneuroinflammation |