Characteristics of haloethylene-induced acetonemia in rats.

6533b7d7fe1ef96bd12684ab

RESEARCH PRODUCT

Characteristics of haloethylene-induced acetonemia in rats.

J. G. Filser H. M. Bolt

subject

Tetrachloroethylene Vinyl Compounds Health Toxicology and Mutagenesis Metabolite Pharmacology toxicology Vinyl Chloride Exhalation General Medicine Fluorine Toxicology Medicinal chemistry Vinyl chloride Dichloroethylenes Rats Acetone chemistry.chemical_compound chemistry Time course Acetone Organic chemistry Animals Fluoride Cysteine

description

A series of halogenated ethylenes (vinyl chloride, vinylidene fluoride,cis- andtrans-1,2-dichloroethylene, perchloroethylene) induces increased acetone exhalation in rats. Exposures of differently pre-treated rats to vinylidene fluoride suggest that a metabolite of the haloethylene must be envolved in eliciting this formation of acetone. This conclusion is based on (a) dependence of acetone exhalation on the concentration of vinylidene fluoride, (b) effect of inducing agents, (c) effect of pyrazol, a metabolic inhibitor, (d) effect of cysteine, (e) effect of hypoxia and (f) the time course of acetone exhalation.

year	journal	country	edition	language
1980-07-01	Archives of toxicology

10.1007/bf01270908 https://pubmed.ncbi.nlm.nih.gov/7469787

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