Increase by ?-adrenolytic drugs of acetylcholine release evoked by field stimulation of the guinea-pig ileum

6533b7d7fe1ef96bd12684da

RESEARCH PRODUCT

Increase by ?-adrenolytic drugs of acetylcholine release evoked by field stimulation of the guinea-pig ileum

subject

Male medicine.medical_specialty Guinea Pigs Alpha (ethology)Ileum Endogeny In Vitro Techniques Phentolamine Ileum Internal medicine medicine Animals Tolazoline Adrenergic alpha-Antagonists Myenteric plexus Pharmacology Chemistry Muscle Smooth General Medicine Acetylcholine Electric Stimulation Yohimbine medicine.anatomical_structure Endocrinology Female Acetylcholine medicine.drug

description

The release of acetylcholine evoked by field stimulation of the guinea-pig ileum (3 Hz) is increased by yohimbine and tolazoline but not affected by phentolamine. It is proposed that yohimbine and tolazoline by blocking alpha-adrenoceptors of the cholinergic nerves abolish the inhibition caused by endogenous noradrenaline, and thus facilitate the output of acetylcholine.

year	journal	country	edition	language
1979-11-01	Naunyn-Schmiedeberg's Archives of Pharmacology

https://doi.org/10.1007/bf00504758

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