6533b7d7fe1ef96bd12685ce

RESEARCH PRODUCT

Soluble Interleukin-2 Receptor Secretion Defectin Vitroin HLA-B8, DR3 Positive Subjects

Maria Assunta ModicaPortelli MrAldo GalluzzoDi Lorenzo GCarla GiordanoCalogero CarusoGiuseppina Candore

subject

AdultMalemusculoskeletal diseasesInterleukin 2medicine.medical_specialtyAdolescentT cellImmunologyStimulationHuman leukocyte antigenBiologyLymphocyte Activationmedicine.disease_causePeripheral blood mononuclear cellAutoimmune DiseasesHLA-B8 AntigenAutoimmunityHLA-DR3 AntigenT-Lymphocyte Subsetsimmune system diseasesInternal medicinemedicineHumansImmunology and AllergyGenetic Predisposition to DiseaseReceptorSicilyCells CulturedImmunologic Deficiency SyndromesReceptors Interleukin-2Middle AgedIn vitroDiabetes Mellitus Type 1medicine.anatomical_structureEndocrinologySolubilityImmunologyLeukocytes MononuclearFemaleDisease SusceptibilityProtein Processing Post-Translationalmedicine.drug

description

Several studies have shown that HLA-B8,DR3 positive subjects may display T cell dysfunctions. Recently, a soluble form of the receptor for IL-2 (sIL-2R) has been demonstrated in human sera and in vitro-stimulated culture supernatant from human T lymphocytes. In the present paper we report sIL-2R serum levels and sIL-2R production from peripheral blood mononuclear cells in HLA-B8,DR3 positive subjects. We found that HLA-B8,DR3 positive subjects have the highest values of serum sIL-2R, but comparing the values of these subjects with those of negative ones no significant difference was observed. As regards the in vitro production of sIL-2R, no difference exists for unstimulated cultures, whereas after stimulation, the HLA-B8,DR3 positive subjects showed the lowest values compared with negative ones. It is noteworthy that these changes are observed in autoimmune diseases linked to this HLA phenotype.

yearjournalcountryeditionlanguage
1990-01-01Autoimmunity
https://doi.org/10.3109/08916939008993381