0000000000300072

AUTHOR

Di Lorenzo G

showing 3 related works from this author

Soluble Interleukin-2 Receptor Secretion Defectin Vitroin HLA-B8, DR3 Positive Subjects

1990

Several studies have shown that HLA-B8,DR3 positive subjects may display T cell dysfunctions. Recently, a soluble form of the receptor for IL-2 (sIL-2R) has been demonstrated in human sera and in vitro-stimulated culture supernatant from human T lymphocytes. In the present paper we report sIL-2R serum levels and sIL-2R production from peripheral blood mononuclear cells in HLA-B8,DR3 positive subjects. We found that HLA-B8,DR3 positive subjects have the highest values of serum sIL-2R, but comparing the values of these subjects with those of negative ones no significant difference was observed. As regards the in vitro production of sIL-2R, no difference exists for unstimulated cultures, where…

AdultMalemusculoskeletal diseasesInterleukin 2medicine.medical_specialtyAdolescentT cellImmunologyStimulationHuman leukocyte antigenBiologyLymphocyte Activationmedicine.disease_causePeripheral blood mononuclear cellAutoimmune DiseasesHLA-B8 AntigenAutoimmunityHLA-DR3 AntigenT-Lymphocyte Subsetsimmune system diseasesInternal medicinemedicineHumansImmunology and AllergyGenetic Predisposition to DiseaseReceptorSicilyCells CulturedImmunologic Deficiency SyndromesReceptors Interleukin-2Middle AgedIn vitroDiabetes Mellitus Type 1medicine.anatomical_structureEndocrinologySolubilityImmunologyLeukocytes MononuclearFemaleDisease SusceptibilityProtein Processing Post-Translationalmedicine.drugAutoimmunity
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HLA-B8,DR3 haplotype affects lymphocyte blood levels

1997

The number of lymphocytes in the blood is constant, pointing to an effective control of circulating lymphocyte values. The mechanisms of this regulation are uncertain, although it is likely that the number of blood lymphocytes is conditioned by hormones, homing factors and cytokines whose production is at least partly restrained by genetic factors. Particularly genetic factors linked to major histocompatibility complex (MHC) appear to be involved. In human beings a decreased number of blood lymphocytes has been described in healthy subjects carrying the Human Leucocyte Antigens (HLA) haplotype HLA-B8,DR3. In the present study, to inquire into the mechanisms of this lymphocyte decreased numb…

AdultMaleLymphocyteImmunologyApoptosisHuman leukocyte antigenMajor histocompatibility complexHLA-B8 AntigenHLA-DR3 AntigenLymphocyte subpopulationsmedicineHumansLymphocyte CountLymphocytesAgedbiologyHaplotypeGeneral MedicineMiddle Agedmedicine.anatomical_structureHaplotypesImmunologybiology.proteinLeucocyte antigensFemaleHormoneHoming (hematopoietic)Immunological Investigations
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Serum Levels of Soluble CD23 in Patients with Asthma or Rhinitis Monosensitive to Parietaria. Its Relation to Total Serum IgE levels and Eosinophil C…

1999

The diagnostic value for allergies of the low affinity IgE receptor and its soluble circulating fragment (sCD23) remains unclear. In particular, little is know about seasonal influences on serum sCD23 levels in subjects with pollen allergy. In the present study, to gain insight into pathophysiological role of sCD23, we have analyzed, in blood from patients allergic to Parietaria sCD23, IgE, and eosinophil cationic protein (ECP) serum levels. IgE were assessed as atopy markers and ECP as an inflammation marker. Patients were studied during and out of pollen season, and results were compared to those obtained in nonallergic subjects. The study population included 42 nonsmoking outpatients, li…

AdultMalePulmonary and Respiratory MedicineAllergyParietariaAdolescentImmunoglobulin EAtopyRibonucleasesHumansImmunology and AllergyMedicinePlant ProteinsAsthmaEosinophil cationic proteinbiologyReceptors IgEbusiness.industryCD23Rhinitis Allergic SeasonalBlood ProteinsGeneral MedicineAllergensEosinophil Granule ProteinsImmunoglobulin EMiddle Agedmedicine.diseasebiology.organism_classificationAsthmaSolubilityImmunologybiology.proteinPollenPopulation studyFemaleImmunizationInflammation MediatorsbusinessAllergy and Asthma Proceedings
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