6533b7d7fe1ef96bd1268667

RESEARCH PRODUCT

Cytotoxicity and antileishmanial activity of Annona muricata pericarp

Sara M. RobledoGabriel J. ArangoM.c. GonzálezM.c. JaramilloIván D. Vélez

subject

Chemical structureAntiprotozoal AgentsEthyl acetateAnnonacinFractionationCell LineLactoneschemistry.chemical_compound4-ButyrolactoneDrug DiscoveryAnimalsHumansFuransMedicinal plantsCytotoxicityAnnona muricataLeishmaniaPharmacologyPlants MedicinalbiologyTraditional medicinePlant ExtractsGeneral Medicinebiology.organism_classificationLeishmania braziliensischemistryBiochemistry

description

Abstract Hexane, ethyl acetate and methanol extracts of Annona muricata pericarp were tested in vitro against Leishmania braziliensis and L. panamensis promastigotes, and against cell line U-937. The ethyl acetate extract was more active than the other extracts and even of Glucantime® used as reference substance. Its fractionation led to the isolation of three acetogenins — annonacin, annonacin A and annomuricin A.

yearjournalcountryeditionlanguage
2000-03-23Fitoterapia
https://doi.org/10.1016/s0367-326x(99)00138-0