6533b7d7fe1ef96bd1268cad

RESEARCH PRODUCT

Specificity and Restriction of T Cells in a System of Complementing Ir Genes

Erwin RüdeAngelika B. Reske-kunzEberhard Spaeth

subject

Surface phenotypeImmune systemAntigenChemistryGene controlchemical and pharmacologic phenomenaStimulationIa antigensGeneBeef insulinCell biology

description

The phenomenon of Ir gene control of immune responsiveness is intimately related to the fact that antigen-specific stimulation of T cells with the Lyt-1 surface phenotype requires the simultaneous recognition of both external antigen and Ia antigen on the surface of antigen-presenting cells. There is increasing evidence indicating that Ia antigens encoded for by the I-A and I-E/C subregions of the H-2 complex represent the products of Ir genes.

yearjournalcountryeditionlanguage
1983-01-01
https://doi.org/10.1007/978-1-4613-3778-2_39